That's a good question. One company in particular that got the designation in October was using p1/2a data on a population less than 20 that did not show cognitive efficacy, simply met some of their bio marker testing parameters at the 4 week mark, so yes it would be possible in designing of this trial I suppose. My guess is they will design with FDA oversight and a discussion of where next to go as expeditiously as possible based on the confirmation results and at that point get the designation, but that's a big guess. If it comes soon as they set this trial up, IMO and others I have talked with, it could be a big share price mover.