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Replies to post #215054 on Innovation Pharmaceuticals Inc (IPIX)
A key aspect of Brilacidin's mechanism of action, inhibiting Phosphodiesterase 4 (PDE4), may further support its use in treating Asthma, Psoriasis, Psoriatic Arthritis and Chronic Obstructive Pulmonary Disease (COPD), alongside other chronic autoimmune conditions.
Score a big win for Pfizer and its $4.5 billion buyout of Anacor Pharmaceuticals. The FDA Wednesday approved Anacor's eczema treatment that is projected to be a $2 billion blockbuster.
The FDA approved Eucrisa (crisaborole) ointment to treat mild to moderate atopic dermatitis, better know as eczema, in patients two years and older. The condition results in red, scaly and extremely itchy crusted bumps.
The phosphodiesterase 4 (PDE-4) inhibitor was tested in two placebo-controlled trials with a total of 1,522 participants that ranged in age from two to 79 years. The FDA said overall, participants receiving Eucrisa achieved greater response with clear or almost clear skin after 28 days of treatment. The FDA said the most common side effect was burning or stinging when the gel was applied.
Pfizer pointed out that approximately 90% of people living with AD have the mild to moderate form of the condition. “The approval of Eucrisa is great news for the children and adults suffering from mild to moderate eczema, a community that has not had a new prescription treatment for more than 10 years,” Albert Bourla, group president, Pfizer Innovative Health, said in a statement.
