Replies to post #42893 on OncoSec Medical Inc (ONCSQ)

[InTheTrenches]

For comparison, Opdivo results in melanoma:

1st trial: Opdivo vs Dacarbazine (chemo):

Opdivo: Complete Response Rate (CRR): 4%, Objective Response Rate (ORR): 34%
Dacarbazine: CRR: 1%, ORR: 9%


2nd trial: Opdivo+Yervoy vs Opdivo vs Yervoy

Opdivo+Yervoy: CRR: 8.9%, ORR: 50%
Opdivo: CRR: 8.5%, ORR: 40%
Yervoy: CRR: 1.9%, ORR: 14%


Opdivo Label: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/125514s012lbl.pdf (pp. 41-44)

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EP IL-12 + Keytruda complete response rate is stunning at >40%