Sox, I suspect the same as you do, especially when adverse effect I know of are from Polymedix ABSSSI trials and don't apply to oral rinse.
One far fetched though thou.
Do you have any idea how and when opioid painkillers are/were administered? I had this off the wall thought that getting opioids may be linked to stage of OM. Say, not anymore so dear doc keeps saying: "you need have stage 3 before I give you opioids". Brilacidin works just enough to keep you teetering at upper limit of stage 2. Plain is bad, but no opioids.
Well, I know I am weak - I would walk out and register to another trial if that would mean getting potent painkillers. But that's just me.