Replies to post #10528 on CytoSorbents Corporation (CTSO)

[orangecat]

It sounds like researchers have determined that elevated cytokines(cytokine storm) creates an environment favorable for tumor growth. Circulating dead cancer cells can trigger elevated cytokines regardless of what killed the cells, be it chemo, radiation, etc. So the elevated cytokines increase the likelihood of the recurrence of cancer. They do not specifically call out CAR T-cell therapy, but from the studies it is apparent that the therapy frequently has the side effect of CRS(Cytokine Release Syndrome).

[Good Sport]

"The blood purification cartridge can be used with most kinds of extracorporeal blood pumps including standard hemodialysis machines, continuous renal replacement (CRRT) machines, heart-lung machines, and extracorporeal membrane oxygenation (ECMO) machines, in any situation where cytokines are elevated. This includes a diverse range of conditions where excessive cytokines and other inflammatory toxins are driving a potentially dangerous inflammatory response. These include acute critical illnesses such as sepsis and infection, burn injury, trauma, acute respiratory distress syndrome, severe acute pancreatitis, liver failure, influenza, cytokine release syndrome in CAR T-cell immunotherapy, and complications of cardiac surgery, as well as in other more chronic diseases such as cancer, cancer cachexia, autoimmune diseases, and others. CytoSorb® is also being used intra-operatively during open heart surgery in a bypass circuit in a heart-lung machine to pre-emptively reduce inflammatory mediators such as cytokines, activated complement, and plasma free hemoglobin that are generated during the surgery and can lead to post-operative inflammation and organ failure. CytoSorb® has been used in more than 14,000 human treatments to date and have been credited with saving many lives"