It sure seems that way sometimes EichKing. Management has truly mislead the longest of the longs like us. Correcting the many false statements and claims on this board, is easy, and I can vent a little. And it keeps me reading more on this company than ever before. Not that doing that is a good thing sometimes. One thing for sure, I hope my pessimistic views are wrong. Never wanted to be more wrong in my life, but nothing has shown otherwise yet.
Now we have claims that possibly they may stop CLI trials early because of great results. Possible, but unlikely imo. The two phase 1's enrolled 27 people. Of them, 4 had major events. Sure it's better than the statistical numbers they compare it to, but the numbers are small, so a little less significant. If we had 100% numbers, would be a little more likely...key word being little. The I/C trial wasn't stopped early. So the further advanced CLI may be harder.
Now as for the timeframe to get interim results. I can base it solely on previous trials. I think it will be some time to recruit 123 patients. We had a ton of sites for the I/C trial, and we all know how long that took. Some suggest a year after. Here's the measures from clinical trial website. Notice most are up to 36 months. Still waiting for Allo to post where they got one year from, but that will never happen. I don't know for sure what length follow up will be. What measures they will use, I don't know. Maybe complete wound healing would suffice. But No matter what, don't see anything until late 2019 at the earliest.
Primary Outcome Measures:
Time to major amputation or death (AFS) [ Time Frame: Up to 36 months from enrollment ]
Secondary Outcome Measures:
Time to first occurrence of any of the events (in index leg)-major amputation,revascularization due to worsening of CLI,doubling of total wound area from baseline,anew gangrene. All-cause mortality. [ Time Frame: Up to 36 months from enrollment ]
Time to major amputation of the index leg. [ Time Frame: Up to 36 months from enrollment ]
Complete wound healing in the index leg [ Time Frame: 12 months from enrollment ]
Ischemic pain (NRS). [ Time Frame: 6 months from enrollment ]
Time to adjudicated major amputation of the index leg or death [ Time Frame: Up to 36 months from
Now if people think we won't get more dilution early 2018 without partnership or government funding or stockpiling, so be it. Only trouble is if we do, price will be horrific. Again people want to think this scenario is impossible, nothing anyone can do to change their stubborn minds. It is a definite and scary possibility. The street keeps us here for a reason. A stock is only worth what one will pay for it, and they only offer less for them than we did 7 years ago. Pathetic!!! Some are new here, so it may take time. Others have changed just like we have. Keep the faith though. I still do.
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