Replies to post #215040 on Biotech Values

[semi_infinite]

MYOK - Phase 1 poster presentation from a while back linked below. I am scratching my head and wonder how in the world the results can be interpreted as positive. Sure pressure gradients went down but look at the drop in LVEF, that would be a disaster in HF patients. The phase 1 cohorts are fairly healthy to begin with with average 65% LVEF to begin with so they can handle some drops in LVEF. This is not something you want to fool around with HF patients. You want LVEF to increase so that the heart have a chance to recover from levels that are usually much lower than 65%. Typical range is 20-40%. If one has oHCM, there is septal alcohol ablation which works well in dropping pressure gradient to normal range without hurting ejection fraction.

http://www.myokardia.com/docs/MyoKardia-Phase-1-Data-AHA-2016-Poster_web.pdf