$PMCB So then, how does Ifosfamide work The trade name is IFEX.
It has been used to treat these cancers
Testicular, Breast, Lymphoma, Soft tissue Sarcomas, Bone, Cervical, Ovarian, Bladder Head and neck
Ifosfamide is chemically related to the nitrogen mustards and is similar in chemical structure to cyclophosphamide (Cytoxan). Ifosfamide is an alkylating agent. Alkylating agents are most active in the resting phase of the cell. These drugs are cell-cycle non-specific. Ifosfamide belongs to the category of mustard gas derivatives.
Ifosfamide is a prodrug which is activated into its cancer killing form by enzymes in the liver. With the Nuvilex CIAB therapy the activating enzymes are encapsulated and placed at the tumor site, which makes for a targeted and more effective treatment.
The cancer cell cycle goes from the resting phase, through active growing phases, and then to mitosis (division). Ifosfamide is most active in the resting phase, and explains why chemo drugs are administered based on the life cycle and growth rate of the cancer cell type. With the PMCB targeted therapy, a much lower dose of Ifosfamide can be used which is non-toxic ie no side effects. Then multiple courses will be administered timed to the resting phase of the tumor cells - that would likely be at 21 day intervals. Courses continued until no additional cell shrinkage can be observed.
The ability of chemotherapy to kill cancer cells depends on its ability to halt cell division
Chemo drugs work by damaging the RNA or DNA that tells the cell how to copy itself in division. If the cells are unable to divide, they die.
The faster the cells are dividing, the more likely it is that chemotherapy will kill the cells, causing the tumor to shrink. Chemo drugs also induce cell suicide (self-death or apoptosis
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