Replies to post #41073 on OncoSec Medical Inc (ONCSQ)

[lasers]

IL-12B is P40

IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.

[ash111]

"significant incentive" for Merck to support the combination, said McCarthy, who keeps a Buy rating and $5 price target on OncoSec shares.
Read more at:
https://thefly.com/landingPageNews.php?id=2625658https://thefly.com/landingPageNews.php?id=2625658

[hschlauch]

Thanks for sharing that article, Guti. It seems abundantly clear that local interferon gamma production is essential to get responses. There is a very strong correlation between interferon gamma fold change and response/nonresponse. It is interesting to see them use a p40 MAB in their study.

In terms of nonresponders to Immunopulse IL-12 in combination with Pembro... do these patients have more p40 expression on tumor cells? Or is it CTLA-4 outcompeting CD28? Or is it limited intratumoral IL-12 expression, perhaps owing to tumor heterogeneity? Or, is it just a matter of pseudoprogression? I think some of these questions will be addressed this week and we will have a better sense of why some patients respond (and respond very well) and some don't.