Replies to post #199899 on Innovation Pharmaceuticals Inc (IPIX)

[joseytheoutlawwales]

Activates P53

[frrol]

Kevetrin activates the p53 pathways, which is a complex statement. There is not just one pathway.

Example: MDM2 attaches to p53 and gets rid of it. Kevetrin is believed to inhibit this, so that p53 can do its job when cell is malignant. This is an "upstream" MOA. It is also transcription-independent.

Kevetrin also mutates, and can become oncogenic. Kevetrin (it is hoped) somehow tags mutant p53 for degradation, avoiding this. This is not "in the stream" at all. Or, more accurately, it is an MOA where Kevetrin de-activates (mutant) p53.

And then Kevetrin also (it is hoped) somehow helps p53 transcribe key proteins needed for cell senescence and apoptosis. It is believed Kevetrin does this by chemically stabilizing the p53 molecule, thus keeping it present and active in the cell.