How can it be approved a monotherapy if the co is not claiming that monotherapy works? As you said there is no arm with VB-111 only.
I think the co is taking the easiest and fastest path to approval, go along with Avastin.
I really think they want to get to market first and then focus on all the potential indications, including monotherapy... for example if the patient experiences a fever in the x number of infusions.