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petemantx

08/16/17 9:39 PM

#193827 RE: georgejjl #193825

Do I interpret your insert regarding the trial that shows a 3:1:3 ratio for the 300, 400, and placebo arms to mean that the 300 and placebo arms will each have 81 patients and the 400 arm only 27 so as to total 189?

mdphd2008

08/17/17 8:39 AM

#193850 RE: georgejjl #193825

I personally don't mind waiting a few short months until December to see full top line results for prurisol trial. Rushing to see interim results may not give as a dramatic effect of efficacy (study was designed with the number of patients chosen to see statistics significance with full enrollment). Interim results are often useful to show safety, however with prurisol, based on the extensive history of abacavir use and it's close similarities, safety is not a major concern. If final trial results were a year away, I would be more curious to see interim results. Again, to me personally, I don't mind the small wait.