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DaubersUP

06/15/17 5:54 PM

#186081 RE: DaubersUP #186080

You know what! Screw it. Let's call for a cure like pre clinical rat models showed!!!!! Tic tic tic
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cabel

06/15/17 6:31 PM

#186086 RE: DaubersUP #186080

Also 46% of a 2 point reduction using the IGA scale is roughly equivalent to 46% PASI90.

So add in the fact we are now dosing 300 and 400mg, we could possibly get to 60% PASI90 with a 80% PASI75.

Where would the price go if we got those numbers,... what would those numbers demand in a deal.

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LilyGDog

06/15/17 9:07 PM

#186113 RE: DaubersUP #186080

Thanks Daubers, science will prevail! Go Leo & IPIX

Thanks! Dont forget the phase 2a psoriasis trial. Mild to moderate patients and a greater or equal to 2 point reduction on IGA. That was truly a tough set of criteria. We found that in the 200mg cohort, patients that took p with the highest score in the moderate stage. (Score of 3) had a 46% rate of scoring the 2 or greater reduction.

That is why we are all so very excited. P is now dosing at 300 and 400 where Prurisol is dose dependent!!!!! Meaning more is better!!!! And because it's an existing drug we tweaked, safety is not an issue!!!!! Most companies right now would have nerves in the phase 2b trial because of the safety UNKNOWN! I think Prurisols drug (can't think of name) was safely dosed at 800-850 mg.

This is so huge and should give everyone here great confidence. We are now dosing moderate to severe patients and at a higher dose. I can only expect we see higher than 46% PASI 75

Jmo