Definitive results showing P53 activation will be HUGE! The path we are taking to target OC is brilliant IMO. Once an MOA is shown/discovered, K will move front and center against the fight of OC and many many other studies by the lucky BP who happens to have the deepest pockets to acquire the rights. Game changer...
Estimated Enrollment: 10 Actual Study Start Date: February 9, 2017 Estimated Study Completion Date: December 31, 2017 Estimated Primary Completion Date: December 31, 2017 (Final data collection date for primary outcome measure) Arms Assigned Interventions Experimental: Cohort 1 Kevetrin 250 mg/m2 IV per dose every other day (q.o.d.)/ 3 doses per week (750 mg/m2 per week), for 3 weeks (single cycle; total 9 doses) Follow-up For 3 weeks after Kevetrin treatment ends Drug: Kevetrin Kevetrin dose to associated cohort Other Name: Cohort Experimental: Cohort 2 Kevetrin 350 mg/m2 IV per dose every other day (q.o.d.)/ 3 doses per week (1050 mg/m2 per week), for 3 weeks (single cycle; total 9 doses) Follow-up For 3 weeks after Kevetrin treatment ends Drug: Kevetrin Kevetrin dose to associated cohort