Replies to post #298385 on Avid Bioservices Inc (CDMO)

[Protector]

hutschi, interesting. This paper proof that the concern expressed in what was posted yesterday (this) holds.

If a small molecule would indeed be bound artificially on the PS on the cell surface THEN the findings of todays paper can not take place.

Rapid catching, whether ionic or covalent bound in bout case require PS to be reachable. If something else in bound on it it cannot play that role.

The findings in this paper clear state that the caught, then released cytokine are the basis of sustained infection combat of the body during processes where cell expose PS (apoptosis or cell corruption). Keeping this from happening will therefor leave the person with high risks of infection and we all know that infections are at the basis of most trouble (and side effects) that more often then the disease itself leads to threatening problems.

[asmarterwookie]

Cool. Thanks Hutschi...looking deeper.

(D) IFNgR KO B16 cells were stained with Annexin V, and the plasma membrane was stained with cell mask orange. Cells were imaged with confocal microscopy
before they could adhere to a dish (to make subcellular detection of PS clearer). Arrows point to PS localized to the plasma membrane. Staining is representative
of two independent experiments

I look forward to the scientists being able to see if the PS exposure is different between Lung and Pancreatic, Breast to Liver, Head Neck to Blader.....etc....

Will there be measurable thresholds of PS exposure for each?

I have to say, probably not but a long time question of mine.

wook