Replies to post #298020 on Avid Bioservices Inc (CDMO)

[Protector]

hutschi, yes. PPHM participated.

This is about PS used in digital imaging (PPHM's antibody PGN635).

Conclusions
In summary, we have demonstrated the utility of PS-targeted liposomal nanoplatform for molecular cancer imaging, in particular, brain tumors imaging via its ability to penetrate the tumor BBB. By encapsulating extremely toxic chemotherapeutic agents, that is, ATO, the PS-targeted delivery of ATO specifically to brain tumors may be useful to treat those malignant brain tumors resistant to the current standard of care, while minimizing its systemic side effects. Furthermore, development of PS-targeted nanotheranostics by incorporating imaging contrast agents with anticancer drugs into the same nanostructure may enable image-guided drug delivery to treat brain tumors. Because PS is the same molecule and has the same distribution and regulation in all mammalian species, it is likely that the mouse data will extrapolate to humans. Along with its favorable safety profile, the PS-targeted lipid-based nanoplatform may be expedited for clinical evaluation of its applicability as a nanocarrier of diagnostic and therapeutic agents for patients with brain tumor.

Acknowledgements
The author would like to pay tribute to the late Dr Philip Thorpe for his pioneered research on phosphatidylserine and development of a series of PS-targeting antibodies. The authors thank Peregrine Pharmaceuticals Inc, Tustin, California, for the provision of PGN635 antibody.

It is this rich collection of applications based on the PS molecule, rather then on PS-receptors on immune system cells, that makes the PS-targeting patents that PPHM holds so valuable.

APPLICATIONS in:

- Cancer Screening (Exosomes)
- Cancer Diagnostics (Exosomes & Digital Imaging)
- Cancer Treatment Follow-up (Exosomes & Digital Imaging)
- Cancer Treatment predictions (Biomarkers)
- Cancer Treatment (Bavituximab & BetaBodies)
- Cancer Treatment Response Follow-up (Exosomes & Digital Imaging)

And of course plenty of applications outside Oncology such as for instance in viral.