Replies to post #24244 on REVE Technologies, Inc (BSSP)

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Here is the news on otcmarkets, also Bloomberg:

Cantech Holding, Inc. (BSSP) Announces Execution of Memorandum of Understanding With the TCM Group for the Creation of a Joint Venture and Development of a New Compound for Inclusion in the Doctor at Home Program in Mexico

MONROVIA, CA -- (Marketwired) -- 05/10/17 -- Cantech Holding, Inc., formerly Reve Technologies, Inc., (OTC PINK: BSSP) (the "Company" or "Cantech") a development stage immunotherapeutic based technology company today announced it has executed a Memorandum of Understanding (the "MOU") between TCM Group ("TCM") and Cantech Intl. Group Mexico ("CIGM"), a to be newly formed unit of Cantech Holding, Inc. for the construction of a manufacturing facility in the city of Tijuana B.C. Mexico. Updating the previously reported August 19, 2016 announcement, and based on several months of discussion and developments the resulting new collaborative joint venture now directly between the principle scientists entities proposes i) TCM will manufacture the specific compound T Cell Modulator and ii) CIGM will manufacture the specific compound Irreversible Pepsin Fraction to be marketed and sold as a newly combined treatment as well as for individual compound applications. All products require authorization to manufacture and sale under the health and sanitary legal framework of Mexico.

Dr. Hector Zepeda Lopez on behalf of TCM, and Harry Zhabilov, CSO of Cantech Holding and on behalf of CIGM will endeavor to form a new compound from the combination of the two existing treatments, T Cell Modulator and the Irreversible Pepsin Fraction to become a registered medicine as part of the application with COFEPRIS for approval and integration into the current Human Studies of the T Cell Modulator to fast track the approval process.

The primary focus of the new compound will be for inclusion in the Health Department of Mexico City "Doctor at Home Program" which has indicated the potential acceptance of Dr. Zepeda's treatment protocol. The "Doctor at Home Program" has been very successful and it is now being franchised to other government health organizations in central and South American countries. Through the joint venture the new compound would be produced for commercial sales nationwide in the United Mexican States and in other Latin American countries participating in the Doctor at Home Program spearheaded by Mexico.

About Canteck Pharma, Inc. IPF for Cancer treatment

Immunotherapy has the potential to provide an alternative and/or complementary treatment in combination with other immune base therapy for several types of cancer. The advantage of immunotherapy over radiation and chemotherapy is that it can act specifically against the tumor without causing normal tissue damage. Current data indicates that immune protection against all cancer requires the generation of a potent cellular immune response against a unique tumor antigen expressed by the malignant cell. As a consequence successful immune protection first requires a unique antigen expressed in the tumor cells (tumor specific antigen) and second, an induction of a potent T-cell immune response, targeted to the tumor antigen.

Unfortunately the immune system by itself can't recognize specific tumor antigens and reject them; however recent advances have revealed that certain proteins binding with specific tumor antigens can be recognized by the immune system, this is what IPF does.

IPF proteins attach to tumor antigens, creating super-antigens (Sags), which increases the number of antibodies against the malignant cells and induces a potent T-cell immune response targeted to the tumor antigen. For a stronger immune response, IPF may be paired with different kinds of adjuvants such as IL-2, IL-6, IL-12 or other cytokines. Another form of immunotherapy can also provide active immunization, which allows for amplification of the immune response. In addition, vaccines can generate a memory immune response. Recent advances have revealed that any cellular protein (expressed in virally infected cells or cancer cells) can be recognized by the immune system if those proteins are presented to the immune system in a form that results in an activation rather than ignorance or tolerance to the antigen. In addition, T-cells rather than B-cells are usually responsible for this recognition.

It is important to point out that when we discuss vaccines for cancer we are referring to treatment rather than prevention, because the antigens expressed by tumor cells (which are the immunogens recognized by the immune system) are not yet known. Attaching known proteins will increase the number of antibodies to fight against them.

This mechanism of action will give us an exact answer (known antigens we have to make known for immune system). In contrast we can use vaccines to prevent infectious diseases because the antigens expressed the causative agent -- fraction and/or its proteins that can attach, serve as the immunogen are already known.