Titan V--Ibalizumab will be live saving for patients CCR5 negative , with resistance to HAART.
It is CD4 inhibitor , and most probably sooner on the market than Pro 140 , but IMO not a very big competition to it.
It is giving as an IV injection every two wks. So patients need to go to clinic or hospital every 2 weeks for IV infusion.
From TaiMed web....."Phase 1/2 clinical trial of SC and IM injection started in 2012 in Taiwan for HIV positive and HIV negative patients.The current available
UN- AUDITED data show tremendous antivirus activity "
All together studies are done as an adjunct treatment only.
I exchanged few e-mails in the past with Dr Chen from TaiMed , and according to him they not planning monotherapy for HIV positive patients.
Monotherapy they doing study only with HIV negative , high risk patients as a prevention.
With adjunct phase 3 ( 30 patients total ) they have 36% patients
accomplished <50 copies/mil viral load.
If we looking at Pro 140 , even without adjusting the dose 62.5% patients on monotherapy did very well , with many patients <1copy/mill viral load.
With adjunct I expect even better.
One patient stop Ibalizumab because developed some immune problems . This is not happening with Pro 140.
For those reasons IMO Pro 140 is superior with CCR5 positive patients.