Do you recall several months ago when Dr. B openly challenged a hit piece by Adam F. about trial results. AF claims in his last rebuttal that Dr. B did not respond to his accusation but skirted around it. No further replies from Dr. B and I'm sure that put some doubts in investors minds. Score one for AF. It's not fair for Leo to take all the blame, enough here to go around. I still think the science is great but not so sure about time, money and management. I was here back in the day when George Evans was replaced by Leo and back then Leo spoke about the little biotech that BP was so interested in and by now it is getting tiresome to hear this over and over. I still think it will, despite management, hit the mother lode. Management has made a bad impression with too large a percentage of investors and each PR gets them further in trouble. Above I mentioned time........Leo get that partnership, it doesn't have to be the best ever formed.