NEWS. Entest BioMedical's Subsidiary, Zander Therapeutics, Inc., Initiates Ex Vivo Studies on Modulating NR2F6 in Canines.
Entest BioMedical Inc.'s (OTCPINK: ENTB) subsidiary, Zander Therapeutics, Inc., has contracted with ChemDiv, Inc., an internationally recognized contract research organization, to test certain NR2F6 modulators licensed to Zander Therapeutics by Regen BioPharma in a cellular system. Specifically, the experiments will determine whether these compounds can suppress or activate the canine immune system. These experiments are performed using a small amount of blood that is drawn from a donor animal. The drugs to be tested are those that have been identified as having a similar cellular effect in human blood.
"This experiment is designed to determine how closely canine cells mimic human cells with respect to NR2F6 modulation. The goal of this study is to determine whether the canine NR2F6 check point can be treated with compounds currently being developed for human use by Regen BioPharma, or if the canine NR2F6 target is significantly different than the human target. In the later case, we will need to do medicinal chemistry tests to make appropriate adjustments to our small molecule therapies for canines," says Harry M. Lander, President and Chief Scientific Officer of Zander.
"This is our first step towards using the synergy afforded by our in-licensed intellectual property," said David Koos, Ph.D., Chairman and CEO of Zander. "We are optimistic the human results can support the science needed to prepare these compounds for use in dogs. This is an important step in developing a small molecule therapy for canines."
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