If you look at the presentation on their web site you will see they take all that into consideration and the realistic market is 10,000 to 20,000 per year.
As of Q4 they were already performing +1000 of carticel at the same price with more stringent rules.
The number of specialists interested enough to train on it is 636, so far,
The number of Carticel was 180 with 100 of them high frequency.