Replies to post #2939 on Synaptogenix Inc (SNPX)

[Maple tree]

----Long term, I believe bryostatin will produce a lot of side effects and adverse events in people with Alzheime----

Very bold statement, and Come back after phase2b result to validate your belief.

[runncoach]

You really don't think bryostatin is neuroprotective? Ask your neurologist about that.

[runncoach]

Read pages 2-3 if nothing else. Not neuroprotective?

http://www.jbc.org/content/early/2016/06/21/jbc.M116.730440.full.pdf

[resident1]

That is not correct. The FDA just needs to approve the open extension, that's all. It might have already been approved.

but those patients won't be able to continue on the drug until AFTER the drug is FDA approved. Is that correct?

Where are the studies that activated synaptogenesis in Alz patients and caused seizures and other issues like you claim? So far there is no proof of this actually being a thing.

I've been informed by a neurologist that unregulated synaptogenesis has a downside, increased incidence of seizures and behavioral/psyche issues for people that have Alzheimers.

A lot of "experts" also say it is a tau and amyloid disease, and poured billions into studies, but we know how that turned out.

Bryostatin does not at all address/correct mitochondrial dysfunction. Many Alzheimers experts describe Alzheimers as a "mitochondrial dysfunction disease".

Those sigma 1 drugs sound amazing, so they already must have showed huge benefit to moderate to severe alzheimers patients then? Can't seem to find the study results...

The sigma 1 drugs show correction of mitochondrial dysfunction (neuroprotection) and also boost synaptogenesis (neurorestoration), tho their synaptogenesis is more measured and regulated for when the neurons need it. Sigma 1 drugs stimulate PKC via M1 receptor stimulation and via releasing calcium from IP3 channels as needed. Sigma drugs treat microglial cells and oligodendrocytes, not just neurons.

[InTheTrenches]

I've been informed by a neurologist that unregulated synaptogenesis has a downside, increased incidence of seizures and behavioral/psyche issues for people that have Alzheimers.

Link to a peer-reviewed journal article please?

[1hb]

Blu 1 - So if three months fixes it or four or seven who says you have to keep dosing..I am sure Dr. Alkon has it covered...he understands your concerns better than any doc you has spoken to imo