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runncoach

03/28/17 2:14 PM

#2621 RE: SF Wolf #2596

I finally got to listen to this first presentation from yesterday. One thing I noted from the 3 PM presentation yesterday was the "pre-dementia" treatment that was mentioned. Dr. Alkon commented on this in the earlier presentation as well and what intrigued me was he said bryostatin completely BLOCKED the damage/issues from ApoE4. I'm no doctor so googled the term and found that it is present in about 20% of people and is a known cause of alzheimer's. Blocking that path would be big it would seem.

https://www.alzdiscovery.org/cognitive-vitality/blog/what-apoe-means-for-your-health

I also noticed when he talked about the CU patient whose mmse score rose from 2 to 12 that he said it maintained that level through the 7 months he received the treatment.
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Amatuer17

03/28/17 6:31 PM

#2628 RE: SF Wolf #2596

The presentation is interesting - the conclusion about multi-modal action suggest that this drug attacks various adverse areas that cause ALZ - sounds like a silver bullet- clearly too good to be true.

Dr was confident and repeated the claim about reversal. Everyone else is talking about just reducing progression and he is talking about reversal. We will see the topline results quite soon.

Another point - AVXL thinks the homeostasis is the right approach to tackle ALZ, NTRP thinks PKC control is the way forward and BP are banking on beta amyloid.
Not sure who is right.