Replies to post #1543 on Synaptogenix Inc (SNPX)

[SF Wolf]

GentleGiant, here is a link to NTRP's Ph2b study:

https://clinicaltrials.gov/ct2/show/record/NCT02431468?term=Neurotrope&rank=1

I am not sure what you are referring to "The reason they only have 6+3 patients" in your post.

[F1ash]

I'm very confident Bryostatin is orally available. IR confirmed they have a patent for a type of Oral delivery.

" Our scientists and engineers have also developed methods for formulating hydrophobic molecules such as bryostatin 1 in stable, readily bioavailable oil-based formulations, and novel nanotechnology formulations of bryostatin 1 that will further improve oral bioavailability. Aphios' Zindol(R) product, which contains oil soluble gingerols and shogaols, recently completed a successful Phase II/III clinical trial for nausea and emesis in cancer patients undergoing chemotherapy"

https://www.sbir.gov/sbirsearch/detail/1753

[InTheTrenches]

GentleGiant:

Good insight on the delivery, but if IV is the only viable delivery, I still believe Bryostatin could be a huge success. Many cancer drugs, which are life-saving, are delivered by IV, and I would put a successful Alzheimer's drug in the same arena as a cancer drug (life-saving).

From another angle, the annual cost of moderate-to-severe AD care is huge, and some analysts believe these AD costs will break Medicare in a few decades. So any drug that lowers the total medical and care costs of AD will be successful, regardless of type of delivery.

In the long run, I don't think a company like Neurotrope has the ability to bring this drug through trials and FDA alone, so I think the endgame will be a partnership with a large Pharma or a buyout. Dr. Alkon has already signaled that with a successful drug, they are willing to partner.

[F1ash]

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"To go to a Phase III is very difficult with this setup. The reason they only have 6+3 patients is because it is extremely expensive to do IV drug studies which tend to be done as an inpatient with nursing support, monitors etc. "
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That was the previous trial description. The pending results will be from the 2b which includes 150 patients in a three arm study (two different doses of Bryostatin and one placebo arm)



https://clinicaltrials.gov/ct2/results?term=Neurotrope+&Search=Search

[HANUMAN]

GG, are you sure it is a facility only infusion therapy? Could it not be IV push, which is very easy to set up in the home, and given by a family member or care giver?