"Are there ever runs before a reverse split?"
Existing shareholders are counseled to use Kaopectate and Imodium to deal with the runs. However, the main problems shareholders have with a reverse split are: nausea, vomiting, sleep disorders, depression, anxiety, and trauma caused by their wife hitting them with a frying pan.
When a pennyscam has YettAnotherCrushingReverseSplit, like PPJE is, the best advice to shareholders is to begin drinking heavily and never stop.