Of the thousands and thousands of penny stocks over the years, how many OTC penny issues have actually uplisted to an Exchange? Less than 10?...and then gone on to any significant success? Any? 1? 2?
Great ideas are not born in the OTC. None of the companies you reference were EVER OTC stocks.
The notion that an OTC issue could be the next Google, Facebook or anything of that level of substance is comical.
When the time for MJ actually comes, it will be private equity and big pharma that will exploit it and develop it.
Not the OTC...it does not allow for the capital structure and investment levels required to truly exploit something that big.
But some folks think it can and hold "long" and eventually lose. Not saying you can't trade on the hype...but long term the OTC is a loss waiting to happen.