Vb111 showed full response in couple of cases that the tumor was very small right after surgery. The patients lived only on vb111 for over 20 month atleast in one case only on vb111. Thyroid results os were great and it was vb111 alone. In ovarian vb111 was combined with chemotherapy but because the girls were sick with platinum resistance ovarian - they don't respond to chemotherapy anyway so this trial although combined with chemo is like monotherapy vb111. Vb111 worked the worst with avastin , I have my theory why because avastin disturb vb111 and not helping it. Anyway u look at it vb111 works great in monotherapy. Regarding ur second question - there was a person in inspire.com forum that was treated in vb111 one shot and his neurologist recommended to stop the trial because he didn't responded to vb111. I asked him did u respond with fever to vb111 he said no.so I figured this no doctor knew that if no fever the no respond otherwise how can u know from one treatment it doesn't work. So I believe this neurologist and other recommend their patients to quit if no fever - it also help the patients - if u have a marker to know if vb111 work or not why not use it to help ur patient. About the avastin arm I believe if they stay for 3,4 treatment they don't quit because u can't quit . If u quit avastin u are done avastin provoke the tumor to become super aggressive if u stop it. From my investigation about avastin almost in every tumor I checked I m not sure it help .in some indication fda found it useless and disallow it like breastfeeding cancer
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