Replies to post #958 on Synaptogenix Inc (SNPX)

[lucylives]

Keep up the good work posting & for your email

My message to the negative folks- Please post links to support your negative statements such as when you mention safety concerns. I'm always interested in all facts good or bad. My guess is you can't. People can say whatever they want but without supporting fact/links. Personally i just ignore those folks

[InTheTrenches]

SF:

Great post. Questionable for anyone to try to minimalize the compassionate use patients and say that we're only relying on mice studies.

By the way, from biggercapital on twitter, it's my understanding that there were 4 treated with compassionate-use, so 3 out 4 showed impressive results.

To follow up on your quote: "No other reports have ever shown comparable benefits in such severely demented patients", below is the text of the slide from the corporate presentation.

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Compassionate Use Patients: Overview
Bryostatin Compassionate Use Program:

Severe Alzheimer’s Disease
No other reports have ever shown comparable benefits in such severely demented patients — albeit in the absence of age-matched controls.

Patient 1 – 95 y/o male (JT) – disoriented, intermittent coma, non-verbal
Course: Became alert, attentive; remembered date, place, time; mind active, engaged, watching TV, requested to return to work.

Patient 2 – 38 y/o female (JS) – familial Early-Onset AD due to PSEN1 mutation, Non-verbal, drooling, unable to swallow (fed with gastrostomy), attention grossly impaired, spasticity, inability to move
Course: Return of some language and vocalization, swallowing, increased attentiveness to environment & persons, increased range of motion

Patient 3 – 76 y/o white ? (FC)
Course: MMSE: 2-3, improved to 10-12; recognizes, vocalizes words. ADCS-ADL-severity score: 18 improved to 33; hallucinations: reduced; Return of complex motor skills — e.g. swimming, billiards.

[doingmybest]

SF Wolf, I agree with your assertion of belief. In the end investors never know everything about a company nor its products in development even in the most deeply developed and communicated situations. I am fine with belief in the management team here. I also think though that it is important to make that decision consciously, meaning with the recognition there is not a deep development trail here, but, there is a credible team of scientists led by a very experienced and credible Dr. Alkon, and, logical and credible, published science. I appreciate the science here, believe it will have at least some success, maybe more, and, I appreciate how the work was performed by BRNI and Dr. Alkon to get it to this point. I am hopeful for success for all involved including and especially all the patients today and tomorrow.