Thus far, PRO 140 has not been linked to toxicity as has many of the oral meds. I listened to the presentation, as well as the Q & A, and IMO Dr. Dhoudy presentation was spot on, as were his answers to the questions directed his way. I could not imagine a better introduction to the CROI audience.
Just happened that oral for HIV are with many side effects . They work on virus , some human organs are also affected.
Pro 140 inhibits entry by CCR5 , but dont really change CCR5 immune responses, so they dont see any immune changes in humans , but immune changes may happen with CD4 inhibitor ( Ibalzumab ) , theoretically at least.
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