Replies to post #23847 on Intellipharmaceutics International Inc. (IPCI)

[doogdilinger]

Exactly mopar great insights!

[WeeZuhl]

The only thing to debate about the blue dye is if it's considered and inactive or active ingredient. Its approved for use as a pharmacologically inactive substance by the fda.

Now we know it doesn't furnish pharmacological activity, cure, mitigate anything, treat, diagnose, or affect the structure or function of the body. The ONLY way you can say it can be considered active is if its used to prevent. Which its not really because if its consumed as it's intended then it acts as an inactive ingredient and really does sweet f' all. That's my take

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You can't have it both ways, Mopar. Either it does something or it does not. If you're argument is that it does nothing then why is it there?




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When any color dye is used to make a tablet look more appealing, that is an inactive ingredient, a general use color additive. For "stigmatizing dye," which deeply discolors human tissue, there is an intended effect on the user, and it causes a change to the user. So it meets the definition of active ingredient no matter how you slice it. But even if you want to call it an inactive ingredient for some strange reason, you still have to recognize that it is a bioactive molecule. It has biological activity that can be studied in vitro and described. In the correct human body compartment (blood) at the necessary dose (unknown) in a particular situation (sepsis), it has a very well-described biological effect (death).

Artificial food dyes can inhibit mitochondrial oxidative phosphorylation in vitro by acting as uncouplers (as does 2,4-dinitrophenol), by blocking electron transport (as does cyanide), or by inhibiting energy transformation by blocking the generation of ATP. Blue dye no. 1, a triphenylmethane dye, is a potent inhibitor of mitochondrial respiration in vitro and reduces oxygen consumption by a factor of eight in mitochondrial preparations in vitro. It appears to inhibit energy transformation by blocking the adenine nucleotide translocator (as is the case with atractyloside).