They are able to bring virus to endothelial cells and even be active and it cause immune response that the lucky patients live 16 months in ovary comparing to 8 without fever response aren't there multiple ways simple ways to play with virus using or other trick like they use in vaccine just to raise chance of fever reaction I m sure it's not a big deal while my advice was just an example by even slightly changing the adnovirus to a different one with different protein in his capsule can do the job I just saying that they never spoke about trying to enhance chance of fever by changing only cosmetic in drug itself by using different carrier of drug
Since u don't need to pass blood brain barrier I don't know if applying it near tumor will change anything the virus get inside all cells in body easily
Regarding dripping in surgery company confirmed by email to me that they intend to offer the use of vb111 right after surgery and consider at that point adding the drug directly to tumor like u offered
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