Replies to post #37581 on OncoSec Medical Inc (ONCSQ)

[goodJohnhunting]

That is correct, although.

My question is; how does this differentiate from Inovio's dmAb technology?

Other than il-12, how do the intend to compete with Inovio's IP?

All the best,
John

[dr_lowenstein]

as I have said many times, yes this can be done, but the essential questions still remain: 1. WHY do this? 2. WHY is no one doing this in the field of PD!? Is there ANY evidence that by doing this with DNA encoding for PD1 that there is superior efficacy to systemic administration. In medicine/science just because something can be done does not mean that it should be done.

[hschlauch]

Efficiency, robust and lasting expression at the site of the checkpoints, safety, and reliability are all reasons for electroporating monoclonal antibody-encoded DNA plasmids, ie checkpoint inhibitors, rather than having them administered systemically. Checkpoint inhibitor combinations administered systemically lead to high toxicity rates.