Replies to post #276647 on Avid Bioservices Inc (CDMO)

[cjgaddy]

A zoom-in of the PS-receptor AXL section in Slide9 from the 10-13-16 ASM.



Raymond Birge(Rutgers) and Rolf Brekken(UTSW, PPHM SAB) and others co-author 2-2016 article, “Phosphatidylserine is a Global Immunosuppressive Signal in Efferocytosis, Infectious Disease, and Cancer” - many references to the Axl PS receptor, like, “Studies with the related TAM receptor Axl provides further mechanistic insight into how PS receptors transmit immune inhibitory signals. Unlike Mertk that is constitutively expressed on macrophages and DCs, under basal conditions the expression of Axl in DCs is low, but is significantly upregulated as a consequence of TLR engagement to resolve and break inflammation in anticipation of the end of an inflammatory cycle… Mertk & Axl are expressed on infiltrating macrophages and DCs, but also frequently expressed on the tumor cells themselves... This combined effect of PS & PS receptors may provide a ‘perfect storm’ that accentuates immune escape.”
http://www.nature.com/cdd/journal/v23/n6/full/cdd201611a.html

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Shareholder Attendee Reports (10-13-16 ASM): http://tinyurl.com/zrv38fl