I updates to Win 10 Build 1607, on 6 laptops, and about 10 VMs, and 2 workstations, with no problems on any of the computers.
The installs did take a while each, but no problems.
I am staying put with Windows Server 2012 R2 and Exchange 2013 for now, as those are more complicated, and the licensing changes of Server do take some thinking about what is the b=est way to set things up.