Replies to post #268961 on Avid Bioservices Inc (CDMO)

[sulaco]

Vin, here's the Mayo Clinic link


Mayo Clinic states Her-2 breast cancer is 20% of all breast cancers

How Many Are HER2-Positive?

The Mayo Clinic estimates that about 20 percent of breast cancers are HER2-positive. Younger women are more likely to be HER2-positive than older women.

HER2-positive breast cancer tends to be more aggressive and to spread more quickly than other cancers. That’s why it’s important to find out if the cancer cells in your body contain this protein.

[vinmantoo]

OK, Vin, it's you against Mayo Clinic

Guess who I'm going with?

The Mayo Clinic estimates that about 20 percent of breast cancers are HER2-positive. Younger women are more likely to be HER2-positive than older women.

What are you talking about? You said 20% express HER2. That is factually incorrect. Tumors deemed HER2 positive are those which OVER-express HER2. It is NOT that only 20% of tumors express HER2. Get it yet? About 20% OVER-express HER2. It is not what you claimed, that only 20% of tumors express HER2. It is the OVER-expression which helps drive tumor progression and that is why blocking that receptors helps most in such tumors. You need to get the basics right if you want people to take you seriously. By they way, here is what the MAYO Clinic says on that and it is EXACTLY what I said.

This is the relevant passage from the link below. Carefully and repeatedly read the FIRST line of the SECOND paragraph.

""HER2-positive breast cancer is a breast cancer that tests positive for a protein called human epidermal growth factor receptor 2 (HER2), which promotes the growth of cancer cells.

In about 1 of every 5 breast cancers, the cancer cells have a gene mutation that makes an excess of the HER2 protein. HER2-positive breast cancers tend to be more aggressive than other types of breast cancer. They're less likely to be sensitive to hormone therapy, though many people with HER2-positive breast cancer can still benefit from hormone therapy.

Treatments that specifically target HER2 are very effective. These treatments are so effective that the prognosis for HER2-positive breast cancer is actually quite good""

http://www.mayoclinic.org/breast-cancer/expert-answers/faq-20058066