Replies to post #4106 on Ayala Pharmaceuticals Inc (ADXS)

[AAstra]

Great points James -- thanks for keeping things in perspective. As many have always said, Opdivo and Keytruda are to market but it is the combo results that will really blow people's minds.

[shub]

There are a number of checkpoint inhibitors out there.
I think CGEN has identified a dozen or so ....But can't get anybody to invest in them.
My guess is that a tumor specific, genetically determined, cluster of checkpoint inhibitors, combined with our constructs would show dramatic results.
Successfully fighting cancer is a multiple modality proposition.
Presently, we tend to try this, and when it doesn't produce a complete cure, we dawdle around and then try that, allowing the tumor to mutate it's way around each medicine. I see that as a mistake.
Instead,we should be attacking the tumor in multiple ways at once, to the extent the patient can tolerate it.