Replies to post #20177 on Intellect Neurosciences Inc. (fka ILNS)

[montanus]

IPA - CNS INFLAMMATION

http://www.nature.com/nm/journal/v22/n6/images/nm.4117-F1.jpg ">http://www.nature.com/nm/journal/v22/n6/images/nm.4117-F1.jpg " />


Following the consumption of such foods, bacteria in the gut catabolize tryptophan into a range of indole derivatives (such as indole-3-acetic acid, indoxyl-3-sulfate, indole-3-propionic acid and indole-3-aldehyde) that are ligands for the aryl hydrocarbon receptor (AHR). Activation of AHR in gut-resident T cells and in innate lymphoid cells (ILC) enhances production of IL-22 (orange circles), which protects against inflammation in the colon (colitis). Tryptophan metabolites also have systemic effects, and signaling through the AHR in astrocytes influences a type 1 IFN signaling pathway, which culminates in both reduced NF-?B-driven inflammation (via SOCS2) and reduced CNS autoimmunity.

http://www.nature.com/nm/journal/v22/n6/fig_tab/nm.4117_F1.html