Replies to post #16291 on Intellipharmaceutics International Inc. (IPCI)

[doogdilinger]

Here's an excerpt from IPCI's CFO 2 years ago explaining IPCI's abuse deterrent properties>>>

What does our Rexista oxycodone do? Well, the main thing that all these products must have is some kind of crush resistance formulation. Rexista has that too, and we have a patent application that recently got published. The reality is all products that are out there can be crushed. If you can go buy a $20 coffee grinder, throw a pill in it, and you are left with some flakes and powder. If you snort our product in the presence of moisture, it's going to get very gummy and pasty and clog up your navel cavities. If you try and pop it in your mouth and inhale it into your lungs like a dry powder inhaler, it will, once again, get clogged up in your throat and you will have to cough it out. If you try to dilute our product in water, it will get very viscous and it's not syringable, so you can't inject it.

If you take that same powder and free base it, which is when you put a powder on a spoon and place a flame underneath it to inhale the vapors, it will spontaneously combust. And if you extract the vapors that come off that burning, there's not much of the oxycodone left, so you will have essentially destroyed our product. If you try to take our once-a-day product with alcohol, that full payload will dump into your body in 1-2 hours, which is very toxic to you. So we see the opposite of dose dumping happening with our product. We've tapered it in such a way that it will release less of the payload in a normal situation, so it actually penalizes patients who try to mix our drug with alcohol. Another way drug addicts are abusing oxycodone is by microwaving it. If you took oxycodone and put it in a microwave for 3 minutes to heat it up, and then let it cool off and proceed to pop it in your mouth, you would get dose dumping. You will have destroyed the abuse deterrent technology in oxycodone. If you do that with our product, however, it doesn't induce dose dumping when you microwave it; it operates completely normal. Furthermore, a way that recreational users abuse oxycodone is by dropping it into a can of Coca Cola, which leads to dose dumping. We don't know what it is about it, but this is one of the ways that drug addicts are abusing it. But again, if you do that with our product, we don't see dose dumping happening.

So, the takeaway here is that we're dealing with a number of different mechanisms of abuse, more so than many different players. We believe that we have the best in class here because we are dealing with abuse deterrents through multiple mechanisms of abuse. We're not aware of anyone that has quite the robustness of abuse deterrent technology in one technology platform and in one product. Sure, Teva is ahead of us, and so is Pain Therapeutics, but it doesn't matter. At the end of the day, even if you get out there 2 years after these guys hit the market, what's a doctor going to prescribe? If the efficacy of the drug works exactly the same as oxycodone, the doctor will likely prescribe the drug that is very difficult to abuse (Rexista) rather than one that is only crush resistant.