biodoc, The waiting game has some concerns/risk. It would be nice to accomplish A,B,C or D and create more value... However, with the stock held hostage on the OTCBB, raising enough capital is going to be a challenge. Trading at 1.55 "with minimal dilution" is a red flag. Trying to build a biotech company without a partnership is going to be tough... The current PPS level will not draw much investment, so will the PPS be attractive enough to raise the proper capital? That's the 1.55 question... It's my opinion that Leo needs to take any partnership ASAP.... By not up-listing has hampered their long-term plans... I believe the PPS would be 3 plus if they up-listed last-year...