This summarizes the previous Phase 1 and Phase 2 Clinical Trials - "The safety of the intra-arterial delivery of the capsules and the lack of evidence that the patients developed an inflammatory or immune response to the encapsulated cells or encapsulation material was shown in all 27 patients." http://www.mdpi.com/1999-4923/6/3/447
Cell-in-a-Box® is completely bioinert, illiciting no immune response. The capsules do not degrade, even after being present in the body for over two years, and they do not cause any damage to, or inflammation of, tissues near where they are located in the body. $$$$$$$$$$$$$$