Replies to post #969 on Alaunos Therapeutics Inc (TCRT)

[jondoeuk]

To my knowledge they haven't published any data. A number of oncolytic viruses are in trials for rGBM like DNX-2401 (1st gen virus) http://neuro-oncology.oxfordjournals.org/content/16/suppl_3/iii39.2.abstract In addition to this the company behind it and Merck have announced a collaboration using the 1st gen virus with pembrolizumab. I also know they are inserting OX40L http://www.ncbi.nlm.nih.gov/pubmed/19426222 which should improve it http://www.ncbi.nlm.nih.gov/pubmed/22396493/ and could be modifying it in others ways too.

You can also make them better in other ways http://www.ncbi.nlm.nih.gov/pubmed/23730207 http://www.ncbi.nlm.nih.gov/pubmed/27141352