The human trial I cited didn't use a synthetic cannabinoid agonist. Also based on some preclinical research like this http://www.ncbi.nlm.nih.gov/pubmed/21475304 then some of the synthetics given at much lower doses (1.5mg/kg v 15mg/kg) work slighter better than the natural. Not that they do much in mice or in humans it seems. If you extrapolate the IC50's then the dosages needed to have any kind of effect are huge. In humans that would be a plasma levels of a few thousands nanograms.
What truth is going to come from Canada within the next few years?.
I personally would legalized all drugs. However the claims this will treat or cure any type of cancer are at current not based on any sound evidence. We need to remember that there are 100 to over 250+ different types of cancer (the actual number depends on how some researchers subdivide some types) in humans. Each of these different cancers have different genetics, different prognoses, different causes, and different treatments. In other words, it is not one singular disease with one unified course of treatment. Every cancer is so different with such different physiology, there is just never going to be a magic treatment. The mutations very from cell to cell, tumour to tumour and person to person even within the same type of cancer. Worse still is the fact that their severe chromosomal abnormalities will worsen as the disease progresses. From this link http://news.wustl.edu/news/Pages/22072.aspx ''50 breast cancer tumours were studied but over 1,700 mutations were found. Most of which were unique to the individual.''
DNX-2401 is a adenovirus and not a enterovirus. It also seems more promising that the trials going on over at Duke and when compared to single agent THC increased the median OS by 5 months and put 3 patients into remissions that were still ongoing at the time the data was published (when does this happen with rGBM?). Even better is that these viruses can be genetically engineered to improve their safety and efficacy. Also they could be used along side checkpoint inhibitors too.
I'd glad GW doesn't have a huge oncology pipeline. I hold out hope for the other Phase III trials ongoing into different types of epilepsy and GWP42004 in T2D, along with some of the other drugs that are in development.
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