I believe the activity would be very long. It has nothing to do with the plasma half life of the IV Brilacidin
The polymer seals to the surface of the implant. It exposes the bacteria to the anionic surface of the Brilacidin polymer and results in bacterial cell membrane rupture using the same mechanism as the IV medicine.
IMO it could be active as long as the polymer remains attached to the implant which could be months or years depending on the surface and the wear the exposed surface is subjected. As an example it would last for a longer time on a pacemaker compared to the articular surface of a knee or hip.
The polymer is the carbon backbone of Brilacidin which is polymerised into a coating in the same way short chain Carbon molecules are converted to plastics.
This technology is absolutely exciting and would be a major medical break through if it proves effective.
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