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grizzlyman

11/16/15 6:40 PM

#130398 RE: rule_rationale #130397

Oh my, I gotta guess I'm not the only one that got confused. I'm not a scientist or a mathmetician. Thank you for clearing that part up.
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biodoc

11/16/15 6:55 PM

#130403 RE: rule_rationale #130397

Dosing is intraperitoneal (IP) dosing in mice. Kevetrin 200mg/kg. Docetaxel 15 and 30 mg/kg. Conversion of animal dosing to human equivalent IV dosing is complicated and was debated at great length some time ago. Bottom line in terms of equivalency in humans: it is believed that the last several cohorts in Phase 1 are well above mouse dosing of 200 mg/kg IP.