Replies to post #242881 on Avid Bioservices Inc (CDMO)

[tradero]

Right Bio,

This is an old post of yours

http://investorshub.advfn.com/boards/read_msg.aspx?message_id=106681471

[Bamboozler762]

Just to help add to your yellow stickies re: Shigekazu Nagata, PhD:

57th ASH Annual Meeting & Exposition The premier event in malignant & non-malignant hematology December 5-8, 2015 Orlando, FL

SCI-31 Flippases and Scramblases at Plasma Membranes that Regulate Phosphatidylserine Exposure Program: Scientific Program Session:Mechanism of Phosphatidylserine Exposure

Saturday, December 5, 2015, 9:30 AM-11:00 AM W312, Level 3 (Orange County Convention Center) Sunday, December 6, 2015, 7:30 AM-9:00 AM W340, Level 3 (Orange County Convention Center) Shigekazu Nagata, PhD

[biopharm]

Board of Directors, ICDS

Patrizia Agostinis; Raymond Birge; Christoph Borner; Marianne Cronje; Katharina D’Herde; Devrim Gozuacik; Roya Khosravi-Far; Simone Fulda; Nader Maghsoudi; Seamus Martin; Soraya Smaili; Eileen White; Junying Yuan; Zahra Zakeri

ICDS Advisory Board

Douglas Green; Marie-Lise Gougeon; Michael Hengartner; H. Robert Horvitz; Marja Jäättelä; Adi Kimchi;Sharad Kumar; Sergio Lavandero; Richard A. Lockshin; Carlos Martínez; Shigekazu Nagata; Don Nicholson; Mauro Piacentini; Jun-Ying Yuan; Boris Zhivotovsky

http://www.celldeath-apoptosis.org/oursoci/board-of-directors.html

If all have been following along, Raymond Birge is self explanatory here as he is one of the latest to speak publicly re: PS Targeting and on the BOD of ICDS, as well Rutgers...

lets not forget our very the direct connection now with Dr. Rolf Brekken who also happens to be guest speaker at ICDS in Cork, Ireland in June

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Now back to expanding on another ... => Devrim Gozuacik

Gozuacik lab’s research theme is cellular stress and death responses. In particular, we focus on autophagy regulation in mammals, autophagy-cell death connection, autophagy-UPS connection and autophagy abnormalities in human diseases including cancer and degenerative diseases.

http://www.researchgate.net/profile/Devrim_Gozuacik

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Autophagy... autophagy... autophagy... hmmmmm, you are probably wondering what the hell is autophagy??

Autophagy is a normal physiological process in the body that deals with destruction of cells in the body.
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Autophagy is seen in all eukaryotic systems including fungi, plants, slime mold, nematodes, fruit flies and insects, rodents (laboratory mice and rats), humans.
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http://www.news-medical.net/health/What-is-Autophagy.aspx

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So yes, if you are still following along, after carefully reading all about autophagy and seeing it exists everywhere, just as flipped-PS exists in plants, animals and humans... we can move forward and yes, flipped PS is required for autophagy...

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Phosphatidylethanolamine from phosphatidylserine decarboxylase2 is essential for autophagy under cadmium stress in Saccharomyces cerevisiae.

Muthukumar K1, Nachiappan V.

Author information

1Biomembrane Laboratory, Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India.

Abstract

Cadmium (Cd) is a potent toxic element used in several industries and in the process contaminates air, soil, and water. Exposure of Saccharomyces cerevisiae to Cd increases the major phospholipids, and profound increase was observed in phosphatidylethanolamine (PE). In yeast, there are four different pathways contributing to the biosynthesis of PE, and contribution to PE pool through phosphatidylserine decarboxylase2 (psd2) is not significant in normal conditions. Upon Cd exposure, psd2? strain showed a significant decrease in major phospholipids including PE. When exposed to Cd, wild-type (WT) cells depicted an increase in ER stress and autophagy, whereas in psd2, ER stress was noted but autophagy process was impaired. The supplementation of ethanolamine did not overcome the Cd stress and also the autophagy process, whereas overexpression of PSD2 in psd2? increased the cellular tolerance, PE levels, and the autophagy process against Cd stress. From our studies, we can suggest that PSD2 of S. cerevisiae has an important role in PE synthesis and in autophagy process under Cd stress.

http://www.ncbi.nlm.nih.gov/pubmed/23743710

Did you read thoroughly the above? I hope so... because we start with connecting some dots from Autophagy <> Flipped PS and now we move to cadmium and Saccharomyces

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Cadmium:

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Biological role

Cadmium has no known useful role in higher organisms,[47] but a cadmium-dependent carbonic anhydrase has been found in some marine diatoms.[48] The diatoms live in environments with very low zinc concentrations and cadmium performs the function normally carried out by zinc in other anhydrases. The discovery was made using X-ray absorption fluorescence spectroscopy (XAFS).[48][49]

The highest concentration of cadmium has been found to be absorbed in the kidneys of humans, and up to about 30 mg of cadmium is commonly inhaled throughout childhood and adolescence.[50] Cadmium can be used to block calcium channels in chicken neurons.[51] Analytical methods for the determination of cadmium in biological samples have been reviewed.[52]
Environment

The biogeochemistry of cadmium and its release to the environment has been the subject of review, as has the speciation of cadmium in the environment.[53][54]

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https://en.wikipedia.org/wiki/Cadmium

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Saccharomyces

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Saccharomyces is a genus in the kingdom of fungi that includes many species of yeast. Saccharomyces is from Greek s???a? (sugar) and µ???? (mushroom) and means sugar fungus. Many members of this genus are considered very important in food production. It is known as the brewer's yeast or baker's yeast. They are unicellular and saprophytic fungi. One example is Saccharomyces cerevisiae, which is used in making wine, bread, and beer. Other members of this genus include the wild yeast Saccharomyces paradoxus that is the closest relative to S. cerevisiae, Saccharomyces bayanus, used in making wine, and Saccharomyces boulardii, used in medicine.

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https://en.wikipedia.org/wiki/Saccharomyces

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So now we are entering "The Enlightenment Age of Disease" and you think PS Targeting is important? Hell yes...

think PS Targeting will be useful in fighting disease within humans, plants and animals? Hell yes...

I'd bring up all the Monsanto posts and Bavi crops posts etc... but all I can think about right now is what better yeast can be used in beer production : )

....possibly some new knowledge will lead to better crop production and is it the yeast or the wheat or the glyphosate that is causing stressed cells/flipped PS to increase and flipped PS is a global biomarker ....

I'd love to hear the whispers between Big Pharma and lobbyists at this time into the FDA.

Remember, big brother may be sitting and waiting and watching for some next moves by some.

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