Replies to post #14701 on Momenta Pharmaceuticals, Inc. (MNTA)

[tony111]

Exciting findings. It has been arugued for a while that Alzheimers is an autoimmune disease but its not clear if its autoantibodies mediated. Perhaps SIF3 will work well in alzheimers.

[DewDiligence]

Alzheimer's is much too common to be eligible for an orphan-drug designation.

[imnot6]

FYI, MNTA, Alhzheimer's, IVIG

http://www.momentapharma.com/docs/mnta-2013-corporate-brochure.pdf
Page 10, 2nd pp:
"Today, global IVIG sales are approximately $7 billion annually. IVIG is approved in several indications, including inflammatory,
infectious, and immunodeficiency diseases, and is also being investigated for use in the treatment of Alzheimer’s disease
and neurological conditions."

http://www.momentapharma.com/docs/publication_synthesis-and-biological-evaluation-of-a-unique-heparin-mimetic-hexasaccharide-for-structure-activity-relationship-studies.pdf
Reference in 5th sentence to "neurodegenerative diseases" referencing footnote #4: Bergamaschini, L.; Donarini, C.; Rossi, E.; De Luigi, A.; Vergani,C.; De Simon, M. G. Heparin attenuates cytotoxic and inflammatory Journal of Medicinal Chemistry ArticleI dx.doi.org/10.1021/jm4016069 | J. Med. Chem. XXXX, XXX, XXX-XXX activity of Alzheimer amyloid-ß in vitro. Neurobiol. Aging 2002, 23,531-536.

http://www.momentapharma.com/docs/4597141_19601T05_CNB%28form_10-K%29.pdf
page 12:
"IVIG is also being investigated for use in the treatment of Alzheimer’s disease and other neurological conditions."

Plus some of Floblu's posts of related patents