Replies to post #237662 on Avid Bioservices Inc (CDMO)

[Couch]

Sounds familiar.....any "collaborations" in Austria???

Biochim Biophys Acta. 2011 Nov;1808(11):2638-45. doi: 10.1016/j.bbamem.2011.07.026. Epub 2011 Jul 26.
In search of a novel target - phosphatidylserine exposed by non-apoptotic tumor cells and metastases of malignancies with poor treatment efficacy.
Riedl S1, Rinner B, Asslaber M, Schaider H, Walzer S, Novak A, Lohner K, Zweytick D.
Author information
1Institute of Biophysics and Nanosystems Research, Austrian Academy of Sciences, Schmiedlstraße 6, A-8042 Graz, Austria.

http://www.ncbi.nlm.nih.gov/pubmed/21810406

Abstract
This study was performed in the aim to identify potential targets for the development of novel therapy to treat cancer with poor outcome or treatment efficacy. We show that the negatively charged phospholipid phosphatidylserine (PS) is exposed in the outer leaflet of their plasma membrane not only in tumor cell lines, but also in metastases and primary cultures thereof, which contrasts with a lack of PS exposure by differentiated non-tumorigenic counterparts. Studied tumor cell lines were derived from non-tumorigenic and malignant melanomas, prostate- and renal cancer, glioblastoma and a rhabdomyosarcoma. Importantly, also metastases of melanoma expose PS and there is a correlation between malignancy of melanoma cell lines from different stages of tumor progression and PS exposure. The PS exposure we found was neither of apoptotic nor of experimental artificial origin. Finally potentially malignant and non-malignant cells could be differentiated by sorting of a primary cell culture derived from a glioblastoma based on PS exposure, which has so far not been possible within one culture due to lack of a specific marker. Our data provide clear evidence that PS could serve as uniform marker of tumor cells and metastases as well as a target for novel therapeutic approaches based on e.g. PS-specific host defense derived peptides.

[biopharm]

Now since flipped PS exists in humans, plants and animals and combination therapy of Bavituximab with many chemos are found to lessen the toxic side affects of the chemo.... is it possible to R&D a combination with many of the plant herbicides / pesticides also such as Roundup ? I say yes... and you know what should further strike a nerve, after realizing that chemo has not been the answer all these years...

The story of Monsanto has been just as quiet as the story of the sabotage against Peregrine Pharmaceuticals and flipped PS exists and can be targeted. Fighting this will not be changed overnight, though ones immune system can optimized immediately and help millions of people, with the help of Peregrine Pharmaceuticals IP pipeline, first up will be Bavituximab. I imagine the collaborations will widen tremendously... soon, hopefully. Monday morning PR ?

Cancer is not a mystery, it is not a stroke of bad luck, it’s time for the world to wake up and realize what research has been confirming for years.

http://www.collective-evolution.com/2015/05/30/why-the-netherlands-just-banned-monsantos-glyphosate-based-herbicides/