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DewDiligence

06/26/06 10:10 AM

#35 RE: bio_me #30

>…what are your thoughts about the risk and side effects of lucentis over a long period of time and do you think the risk increases once a person starts treatment in both eyes.<

The ophthalmic risk from Lucentis doubles if both eyes are treated.

It’s unclear to what extent the systemic risk from Lucentis changes if both eyes are treated; in fact, it’s unclear if there is any bona fide systemic risk because so little drug escapes from the vitreal chamber into the general circulation.

The Lucentis PDUFA date is this Friday, so we’ll soon find out what the FDA thinks about all this.
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DewDiligence

06/26/06 10:15 AM

#36 RE: bio_me #30

>As far as genr being a quasi-legit scam, that is a pretty strong statement, and I'm wondering what leads you to believe this? Can you be clear and specific about the doubts you have concerning the legitimacy of this company?<

My definition of a quasi-legit scam is a company that continues clinical programs that have a low likelihood of success because canceling them would jeopardize the company’s ability to raise capital and continue paying salaries and bonuses to the executives.