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DewDiligence

09/01/15 1:09 PM

#194725 RE: iwfal #194724

TRVN—…I want to see better data on addiction potential because if it still produces the high then my guess is it becomes more difficult to market (vs all the anti-abuse opioids).

In the acute, in-hospital setting, which TRVN is targeting, abuse deterrence should be less consequential than in the chronic setting.

I think the reduction of OIC for their oral drug would be a stronger driver [than reduction in respiratory distress]…

We can probably infer from the lack of discussion of OIC that TRV130 doesn’t confer a material benefit there.