So the drug will be efficacious based on increases in p21?
What a shame they have to prove ,then, that it actually works to reduce tumor size or increase survival
Too bad they cannot stop now, and tell patients that their p21 will go up and they will get better.
Oh wait- maybe their p21 will go up and it won't matter clinically. (What a hassle. The burden of proof in a clinical trial- must we go through it? Oh yeah- that's how it works)